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Cheng Luo Selected Research

Protein-Arginine N-Methyltransferases (Methyltransferase, Protein Arginine)

1/2021PRMT1 is a novel molecular therapeutic target for clear cell renal cell carcinoma.
1/2019Rational Design, synthesis and biological evaluation of novel triazole derivatives as potent and selective PRMT5 inhibitors with antitumor activity.
12/2018Identification of 5-benzylidene-2-phenylthiazolones as potent PRMT5 inhibitors by virtual screening, structural optimization and biological evaluations.
1/2018Identification of Selective, Cell Active Inhibitors of Protein Arginine Methyltransferase 5 through Structure-Based Virtual Screening and Biological Assays.
11/2017Development of Potent Type I Protein Arginine Methyltransferase (PRMT) Inhibitors of Leukemia Cell Proliferation.
5/2017Discovery and optimization of selective inhibitors of protein arginine methyltransferase 5 by docking-based virtual screening.
1/2016Identification of Novel Inhibitors against Coactivator Associated Arginine Methyltransferase 1 Based on Virtual Screening and Biological Assays.
1/2013Theoretical insights into catalytic mechanism of protein arginine methyltransferase 1.

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Cheng Luo Research Topics

Disease

116Neoplasms (Cancer)
10/2022 - 05/2004
19Inflammation (Inflammations)
04/2022 - 01/2005
17Leukemia
01/2022 - 01/2014
14Carcinogenesis
01/2022 - 05/2008
13Schizophrenia (Dementia Praecox)
10/2022 - 01/2017
13Mitochondrial Diseases (Mitochondrial Disease)
10/2014 - 06/2006
9Infections
01/2022 - 06/2003
9Type 2 Diabetes Mellitus (MODY)
01/2021 - 04/2012
9Prostatic Neoplasms (Prostate Cancer)
01/2020 - 07/2012
8Breast Neoplasms (Breast Cancer)
01/2022 - 09/2017
8Renal Cell Carcinoma (Grawitz Tumor)
12/2021 - 12/2016
8Glaucoma
12/2012 - 03/2007
7Hepatocellular Carcinoma (Hepatoma)
04/2022 - 04/2013
7Idiopathic Generalized Epilepsy
01/2022 - 06/2012
7Insulin Resistance
02/2021 - 10/2014
6Temporal Lobe Epilepsy
08/2022 - 07/2013
6Obesity
01/2022 - 08/2013
6Hypoxia (Hypoxemia)
01/2022 - 09/2014
5Pain (Aches)
12/2022 - 01/2015
5Epilepsy (Aura)
01/2022 - 05/2012
5Metabolic Syndrome (Dysmetabolic Syndrome X)
12/2021 - 03/2017
5Myocardial Infarction
10/2021 - 01/2005
5Cognitive Dysfunction
01/2021 - 06/2014
5Fibrosis (Cirrhosis)
01/2021 - 01/2013
5Lymphoma (Lymphomas)
01/2020 - 11/2014
5Autoimmune Diseases (Autoimmune Disease)
09/2019 - 01/2012
4Liver Cirrhosis (Hepatic Cirrhosis)
04/2022 - 01/2021
4Neoplasm Metastasis (Metastasis)
01/2021 - 08/2019
4Osteosarcoma (Osteogenic Sarcoma)
10/2020 - 07/2017
4Infarction (Infarctions)
01/2019 - 05/2018
4Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung)
01/2019 - 01/2013
4Lung Neoplasms (Lung Cancer)
10/2017 - 11/2012
4Multiple Sclerosis
10/2015 - 01/2014
4Parkinson Disease (Parkinson's Disease)
01/2015 - 12/2008
3Seizures (Absence Seizure)
01/2022 - 12/2009
3Ovarian Neoplasms (Ovarian Cancer)
12/2021 - 10/2017
3Neurodegenerative Diseases (Neurodegenerative Disease)
11/2021 - 02/2013
3Hypertension (High Blood Pressure)
08/2021 - 01/2013
3Colonic Neoplasms (Colon Cancer)
04/2021 - 08/2014
3Ischemic Stroke
01/2021 - 01/2019
3Cardiovascular Diseases (Cardiovascular Disease)
01/2021 - 01/2013
3Bone Fractures (Bone Fracture)
10/2020 - 01/2017
3Ischemia
02/2020 - 05/2018
3Triple Negative Breast Neoplasms
01/2020 - 07/2017
3Heart Failure
02/2019 - 01/2013
3Stroke (Strokes)
01/2019 - 08/2005
3Mental Disorders (Mental Disorder)
10/2017 - 02/2013
3Necrosis
03/2015 - 06/2010

Drug/Important Bio-Agent (IBA)

50Proteins (Proteins, Gene)FDA Link
01/2022 - 06/2003
34Pharmaceutical PreparationsIBA
01/2022 - 05/2004
21EnzymesIBA
12/2021 - 08/2005
18MethyltransferasesIBA
01/2022 - 11/2014
11Histones (Histone)IBA
12/2021 - 02/2014
11Biological ProductsIBA
12/2021 - 07/2012
9LipidsIBA
04/2022 - 02/2008
9Glucose (Dextrose)FDA LinkGeneric
02/2022 - 09/2015
9CytokinesIBA
01/2022 - 01/2012
9DNA (Deoxyribonucleic Acid)IBA
09/2021 - 12/2006
9Biomarkers (Surrogate Marker)IBA
09/2020 - 01/2012
8Arginine (L-Arginine)FDA Link
01/2022 - 01/2013
8Immunoglobulin E (IgE)IBA
01/2022 - 05/2012
8Lysine (L-Lysine)FDA Link
12/2021 - 08/2015
8Protein-Arginine N-Methyltransferases (Methyltransferase, Protein Arginine)IBA
01/2021 - 01/2013
6Antipsychotic Agents (Antipsychotics)IBA
01/2022 - 01/2017
6Phosphotransferases (Kinase)IBA
01/2018 - 10/2008
5RNA (Ribonucleic Acid)IBA
04/2022 - 04/2017
5Reactive Oxygen Species (Oxygen Radicals)IBA
05/2021 - 10/2013
5Polysaccharides (Glycans)IBA
01/2017 - 11/2012
5Retinaldehyde (Retinal)IBA
12/2012 - 10/2010
4CholesterolIBA
04/2022 - 07/2013
4Transcription Factors (Transcription Factor)IBA
01/2022 - 02/2014
4Long Noncoding RNAIBA
11/2021 - 01/2018
4nitroxolineIBA
01/2020 - 11/2017
4Anti-Bacterial Agents (Antibiotics)IBA
02/2019 - 01/2011
4PlatinumIBA
03/2018 - 07/2017
4AntioxidantsIBA
01/2018 - 04/2008
4Antineoplastic Agents (Antineoplastics)IBA
07/2017 - 03/2014
4Interleukin-23 (Interleukin 23)IBA
05/2016 - 01/2012
4Acrolein (Aqualin)IBA
03/2015 - 06/2006
3Adenosine Triphosphatases (ATPase)IBA
01/2022 - 01/2014
3ChromatinIBA
01/2022 - 11/2021
3Adenosine Triphosphate (ATP)IBA
11/2021 - 08/2014
3Peptides (Polypeptides)IBA
09/2021 - 10/2018
3CeramidesIBA
04/2021 - 01/2014
3Insulin (Novolin)FDA Link
02/2021 - 03/2015
3Messenger RNA (mRNA)IBA
01/2021 - 01/2015
3Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
01/2020 - 06/2010
3Fingolimod Hydrochloride (FTY720)FDA Link
01/2020 - 01/2014
3Triglycerides (Triacylglycerol)IBA
01/2020 - 08/2014
3Histone MethyltransferasesIBA
12/2019 - 10/2015
3ErbB Receptors (EGF Receptor)IBA
08/2019 - 05/2004
3MicroRNAs (MicroRNA)IBA
04/2019 - 10/2013
3TOR Serine-Threonine KinasesIBA
01/2019 - 01/2009
3Therapeutic UsesIBA
01/2019 - 01/2018
3Pyruvic Acid (Pyruvate)IBA
01/2019 - 07/2013
3Cyclooxygenase 2 (Cyclooxygenase-2)IBA
04/2013 - 05/2008

Therapy/Procedure

47Therapeutics
04/2022 - 12/2008
4Anterior Temporal Lobectomy
08/2022 - 01/2019
4Drug Therapy (Chemotherapy)
06/2022 - 11/2014
4Immunotherapy
01/2022 - 09/2015